1. Chapter 2

2. Amino acids

3. Protein structure Primary:

4. Protein structure Secondary:

5. Protein structure Tertiary:

6. Protein structure Quaternary:

8. Protein as drug targets Not very common Fuzeon (enfuvurtide): anti-HIV drug - polypeptide of 36 units injected subcutaneously Zoladex (goserelin): prostate and breast cancer treatment (made $700 million last year)

9. Post-translational Modifications Modifications of proteins after translation have a wide range of effects. Scurvy Excessive bleeding Cell to cell recognition, disease processes, drug treatments Enzyme regulation through protein cleavage

10. Proteomics Genomics- process to identify the genetic code Proteomics – process to identify all proteins in each cell of the body and how they interact with each other More complex than genomics because of the many interactions between proteins.

11. Drug action at proteins Structural Proteins Typically not drug targets (exception tublin) Transport Proteins Several important drugs target transport proteins Enzymes & Receptors Most important drug targets Many cell processes depend on the interactions of proteins with each other promoting or inhibiting these processes could lead to many novel drug compounds

12. Structural proteins Tubulin

13. Carrier proteins

14. Examples of drugs that can move into the cell

15. Carrier proteins Drugs that block the binding site of carrier proteins