1. TRANSCRIPTION AND TRANSLATION: THE ROAD TO MAKING PROTEINS Part 1: Transcription (p 424) Investigative Question: What is RNA? What is Transcription?

2. TRANSCRIPTION AND TRANSLATION: The Road to Making Proteins  The classroom is set up to represent a CELL  The DNA is located in the NUCLEUS.  The NUCLEAR membrane allows passage in and out of the nucleus.  The walls of the room represent the CELL MEMBRANE  The lab stations represent RIBOSOMES

3. TRANSCRIPTION  Carefully read “Making RNA” (p 425). Be sure to look at Figure 8.16.  Look for details about RNA and transcription.  Take notes in a “Note Box”.

4. TRANSCRIPTION BIG IDEAS  Transcription occurs in the nucleus.  Transcription “copies” the code from a section of DNA (a section of DNA = a gene!).  mRNA is produced during transcription. (m = messenger)  RNA polymerase is the enzyme that controls transcription.  mRNA leaves the nucleus, carrying the information from the DNA.  Structurally, RNA differs in 3 ways from DNA.  Sugar is Ribose  Thymine replaced by Uracil  Single stranded

5. TRANSCRIPTION  Follow along as we model the process of transcription. Make sure to record what we do as directed.

6. TRANSCRIPTION PRACTICE  From your lab group, select 1 person to act as RNA polymerase. (they will do the actual transcription and proofreading of the new mRNA)  The RNA polymerase person from each group must go into the nucleus, find their gene, and transcribe it. The newly made mRNA now travels to the ribosome.  Each person in the lab group must now copy the mRNA into their lab notebook. (Leave room above)  Go backwards and record the original DNA strand above your mRNA.