1. Extension 能否經由抑制 Lipase 來治療青春痘 ? Acne vulgaris 由 Propionibacterium acnes 引起 Lipase

2. Victoria Blue B

4. MTT test for inhibition of P.acnes by SACCHACHITIN SA CK

6. Tyrosinase inhibition? 美白 ?

7. Melanin production Melanoma cell line SA 0.1% CK

8. Conea repair 眼角膜創傷治療 不溶於水，如何成為眼藥水 ? 微米化 ( 直徑 2  m)

9. 微粒化 SACCHACHITIN

10. SEM SACCHACHITIN

11. SEM Micronized SACCHACHITIN

12. MMP: Rabbit B

13. Experimental Group Control Group Fluorescein staining: Rabbit B

14. Normal Cornea

16. Experimental Group 200X 96hr Normal Conea Control Group 200X 96hr

17. SACCHACHITIN 之劑型 膜 軟膏 微粒化懸浮液

18. Cells 細胞 Growth Factors Biomaterials Tissue regeneration 生長因子 生物材料

19. References 1.Su, C.H., C.H. Sun, S. W. Juan, C. H. Hu, W. T. Ke, M. T. Sheu 1997 Fungal mycelia as the source of chitin and polysaccharides and their application as skin substitutes. Biomaterials 18:1169-1174 2. Su CH, Sun CS, Juan SW, Ho HO, Hu CH and Sheu MT 1999.Development of fungal mycelia as skin substitutes: Effects on the wound healing process. NTJM.(1):31-39. 3. Su CH, Sun CS, Juan SW, Ho HO, Hu CH and Sheu MT 1999 Development of fungal mycelia as skin substitutes: Effects on wound healing and fibroblast. Biomaterials.(20):61-68. 4. Huang WS, Fang CL, Su CH, Lai WF, Chang WC, and Tsai YW 2001 Cytotoxicity and immunogenecity of SACCHACHITIN and its mechanism of action on skin wound healing. J. Biomedical Research.(56):93-100. 5. Hung WS, Lai WF, Leu B, Su CH, Fang CL, Tsai.YH 2004 Effect of SACCHACHITIN on keratinocyte proliferation and the expressions of type I collagen and tissue-transglutaminase during skin wound healing. Journal Biomedical Material Research Part B: Applied Biomaterials.(70B):122-129. 6. Su CH, Liu SH, Yu SY, Hsieh YL, Ho SO, Hu CH, Sheu MT 2005.Development of fungal mycelia as a skin substitute:Characterization of keratinocyte proliferation and matrix metalloproteinase expression during improvement in the wound-healing process. Journal of Biomedical Materials Research Part A.(72A):220-227.