1. Hormone Actions
SC.912.L.14.31

2. Essential Question
How do hormones work?

3. Hormones Chemicals secreted into blood Steroids or proteins
Act on only on distant target organs that have receptors for the hormone
Act until they are cleared from the blood by liver or kidney.

4. Lipid Soluble Hormones
Type of Receptor
Intracellular receptors (cytoplasm and/or nucleus)
Types of hormones
Steroids and thyroid hormones
Action in cell
Alters gene expression
Examples:
Estrogen, Testosterone, Thyroid Hormone, Aldosterone, Cortisol

5. Water Soluble Type of Receptor Types of hormones Action in Cell
Cell surface receptors (plasma membrane)
Types of hormones
Proteins and peptides, catecholamines and eicosanoids
Action in Cell
Generation of second messengers which alter the activity of other molecules - usually enzymes - within the cell
Examples: ADH, FSH, TSH, Epinephrine, Insulin

6. Mechanism of action of hormones
Membrane permeability
Protein synthesis
Deactivation /activation of enzymes
Secretory activity triggered
Cell division stimulated
Action depends on
Level of circulating hormone
# of receptors
Affinity of receptors

7. Negative Feedback
Most hormones are controlled by negative feedback. As the hormone brings the body back into balance less of it is produced.

8. Through another protein
Day 2 -
Hormones
Fat Soluble
Inside Cell
Direct
Water Soluble
Outside cell
Through another protein
From your cornell notes complete this concept map.

9. Day 2 - From your cornell notes complete this concept map. Hormones
______Soluble
_________
_____________
______________
________________
From your cornell notes complete this concept map.